Levonorgestrel Emergency Contraceptive

Levonorgestrel tablets, 0.75 mg may be a progestin-only emergency contraceptive indicated for interference of maternity following unprotected intercourse or a noted or suspected contraceptive failure. to get optimum efficaciousness, the primary pill ought to be taken as shortly as doable among seventy two hours of intercourse. The second pill ought to be taken twelve hours later.

Levonorgestrel tablets, 0.75 mg is accessible solely by prescription for ladies younger than age seventeen years, and offered over the counter for ladies seventeen years and older. Levonorgestrel tablets, 0.75 mg isn't indicated for routine use as a contraceptive.

Levonorgestrel Emergency Contraceptive dose and Administration

Take one pill of Levonorgestrel tablets, 0.75 mg orally as shortly as doable among seventy two hours when unprotected intercourse or a noted or suspected contraceptive failure. efficaciousness is best if the pill is taken as shortly as doable when unprotected intercourse. The second pill ought to be taken twelve hours when the primary dose. Levonorgestrel tablets, 0.75 mg are often used at any time throughout the oscillation. If unconditioned reflex happens among 2 hours of taking either dose of medication, thought ought to run to repetition the dose.

Dosage Forms and Strengths

Each Levonorgestrel tablets, 0.75 mg pill is equipped as a white to off-white circular, flat beveled, uncoated pill debossed with "L840" on one aspect and plain on the opposite aspect.

Contraindications

Levonorgestrel tablets, 0.75 mg is contraindicated to be used within the case of noted or suspected maternity.

Warnings and Precautions

Ectopic pregnancies account for about a pair of of all rumored pregnancies. Up to 100 percent of pregnancies rumored in clinical studies of routine use of progestin-only contraceptives ar position. A history of gestation isn't a reason to use of this emergency birth control. attention suppliers, however, ought to contemplate the chance of AN gestation in girls UN agency become pregnant or complain of lower abdominal pain when taking Levonorgestrel tablets, 0.75 mg. A follow-up physical or girdle examination is usually recommended if there's any doubt regarding the final health or maternity standing of any girl when taking Levonorgestrel tablets, 0.75 mg.

Existing maternity

Levonorgestrel tablets, 0.75 mg isn't effective in terminating AN existing maternity.

Effects on emission

Some girls could expertise recognizing many days when taking Levonorgestrel tablets, 0.75 mg. emission injury patterns ar usually irregular among girls victimisation progestin-only oral contraceptives and girls victimisation levonorgestrel for postcoital and emergency birth control. If there's a delay within the onset of expected emission on the far side one week, contemplate the chance of maternity.

STI/HIV

Levonorgestrel tablets, 0.75 mg doesn't shield against HIV infection (AIDS) or alternative sexually transmitted infections (STIs).

Physical Examination and Follow-Up

A physical examination isn't needed before prescribing Levonorgestrel tablets, 0.75 mg. A follow-up physical or girdle examination is usually recommended if there's any doubt regarding the final health or maternity standing of any girl when taking Levonorgestrel tablets, 0.75 mg.

Fertility Following termination

A fast come of fertility is probably going following treatment with Levonorgestrel tablets, 0.75 mg for emergency contraception; thus, routine birth control ought to be continuing or initiated as shortly as doable following use of Levonorgestrel tablets, 0.75 mg to make sure current interference of maternity.

Adverse Reactions

Clinical Trial expertise

Because clinical trials ar conducted below wide varied conditions, adverse reaction rates determined within the clinical trials of a drug can't be directly compared to rates within the clinical trials of another drug and will not replicate the rates determined in clinical follow.

A double-blind, controlled test in one,955 evaluable girls compared the efficaciousness and safety of levonorgestrel tablets, 0.75 mg (one zero.75 mg pill of levonorgestrel taken among seventy two hours of unprotected intercourse, and one pill taken twelve hours later) to the Yuzpe regime (two tablets every containing zero.25 mg levonorgestrel and zero.05 mg ethinyl estrogen, taken among seventy two hours of intercourse, and 2 tablets taken twelve hours later).

The most common adverse events (> 10%) within the test for ladies receiving levonorgestrel tablets, 0.75 mg enclosed emission changes (26%), nausea (23%), abdominal pain (18%), fatigue (17%), headache (17%), vertigo (11%), and breast tenderness (11%). Table one lists those adverse events that were rumored in > five-hitter of levonorgestrel tablets, 0.75 mg users.

Mechanism of Action

Emergency contraceptive pills don't seem to be effective if a girl is already pregnant. Levonorgestrel tablets, 0.75 mg is believed to act as AN emergency contraceptive chiefly by preventing organic process or fertilization (by sterilisation bodily structure transport of spermatozoan and/or ova). additionally, it's going to inhibit implantation (by sterilisation the endometrium). it's not effective once the method of implantation has begun.

Clinical Studies

A double-blind, randomized, international controlled test in one,955 evaluable girls (mean age 27) compared the efficaciousness and safety of levonorgestrel tablets, 0.75 mg (one zero.75 mg pill of levonorgestrel taken among seventy two hours of unprotected intercourse, and one pill taken twelve hours later) to the Yuzpe regime (two tablets every containing zero.25 mg levonorgestrel and zero.05 mg ethinyl estrogen, taken among seventy two hours of intercourse, and 2 extra tablets taken twelve hours later). when one act of intercourse occurring anytime throughout the oscillation, the expected maternity rate of 8 May 1945 (with no contraceptive use) was reduced to more or less a hundred and twenty fifth with levonorgestrel tablets, 0.75 mg.

At the time of expected emission, more or less seventy four of ladies victimisation levonorgestrel tablets, 0.75 mg had channel injury just like their traditional emission, 14 July bled over usual, and twelve-tone system bled but usual. the bulk of ladies (87%) had their next emission amount at the expected time or among +7 days, whereas thirteen had a delay of over seven days on the far side the anticipated onset of emission.

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